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No, is not a mutation. Blood antigens cannot 'mutate' in womb to repel mother's Rhesus macaque blood antigens (hemolytic disease would make this impossible.) And the fact O- is universal donor, points towards more purity and less alteration than all other types. If anything is a real proof of hybridization. Neanderthal had RH- blood type and Homosapiens RH+
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